Animal Models of Addiction

Animal Models of the Preoccupation/Anticipation Stage of the Addiction Cycle

A defining characteristic of addiction is its chronic, relapsing nature. Animal models of relapse fall into three general conditioning constructs: (1) drug-induced reinstatement, (2) cue-induced reinstatement, and (3) stress-induced reinstatement (Table 3.4). The general conceptual framework for this conditioning conceptualization is that cues, both internal and external, can become associated with the positive and negative reinforcing actions of drugs and abstinence through classical conditioning, which can then elicit drug use.

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