Animal Models of the Preoccupation/Anticipation Stage of the Addiction Cycle

Drug-Induced Reinstatement

The persistence of drug seeking behavior in the absence of response-contingent drug availability can be measured using extinction procedures, but extinction is also a key element of most animal models of relapse. When noncontingent drug injections are administered after extinction, they increase responding at the lever that previously delivered the drug. Such responding is called drug-induced reinstatement (Stewart and de Wit, 1987; Figure 3.12).

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