Effects of Known Medications on Animal Models of Addiction – Reverse Validity (Rosetta Stone Approach)

Seven medications are currently on the market in the United States for the treatment of addiction, including (in chronological order of US approval) disulfiram (Antabuse), methadone (Dolophine), nicotine substitution (gum, lozenge, patch), naltrexone (ReVia, Vivitrol), bupropion (Zyban), buprenorphine (Subutex, Suboxone), acamprosate (Campral), and varenicline (Chantix; Figures 9.29.4, Tables 9.29.4). One validation procedure has been termed the “Rosetta Stone” approach (or “reverse validity” approach). Drugs that are known to be effective in human clinical studies can be used to validate animal models, and human laboratory models can provide a means of refining such models.

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